DU led 17-16 in the first half but fell behind by 12 at halftime and never recovered.
The Pioneers cut the Coyote’s lead to nine when Daniel Amigo’s offensive rebound and put-back made it 51-42, but it was the only time South Dakota let its advantage dip below double figures in the second half.
Amigo led Denver (6-9) with 17 points. Jake Pemberton added 14.
Last year’s Summit League Newcomer of the Year Matt Mooney turned in a game-high 20 points for USD (13-4).